Resveratrol improves health and survival of mice on a high-calorie diet
Article Abstract:
A study was conducted to show that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Parametric analysis of gene set enrichment revealed that resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways which show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Article Abstract:
A study is conducted to report that serum retinol binding protein 4 (serum RBP4) is elevated in adipose tissue of adipose-Glut4 mice and that serum RBP4 levels are elevated in several insulin-resistant states in mice and humans. The results establish that the RBP4-transthyretin interaction is a new target for the development of drugs to combat insulin resistance and type 2 diabetes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
Article Abstract:
Research is presented concerning the influence of the glucose transporter GLUT4 in the decreased glucose metabolism and transport in adipocytes and muscle on the development of the type 2 form of diabetes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Residue-based control of helix shape in beta-peptide oligomers. Non-haemolytic beta-amino-acid oligomers
- Abstracts: Alternative feeding strategies and potential disease transmission in Wisconsin white-tailed deer. Sex affects age determination and wear of molariform teeth in white-tailed deer
- Abstracts: Temperature terrestrial vertebrate faunas in North and South America: interplay of ecology, evolution, and geography wit biodiversity
- Abstracts: Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Sperm and mammalian polarity
- Abstracts: The neocortex comes together. Radial mosaicism and tangential cell dispersion both contribute to mouse neocortical development