Role for a Xenopus Orc2-related protein in controlling DNA replication
Article Abstract:
Origin recognition complex (ORC) plays an important role in starting DNA replication in the yeast Saccharomyces cerevisiae. A significant research topic is whether the occurrence of DNA replication in higher eukaryotes is facilitated by a mechanism that relies on ORC. A Xenopus laevis Orc-2-related protein (XORC2) is isolated. It is shown that XORC2's immunodepletion eliminates the replication of chromosomal DNA and that it firmly attaches itself to chromatin before DNA synthesis starts. The results of the analysis point to the vital role played by Orc2 in the early phase of chromosomal replication in animal cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Springtime in the desert
Article Abstract:
The 3' inch end of the messenger RNA in animal cells was long considered to be devoid of any important messages, and was seen as transferring information that was only necessary to form the end of the RNA. Recent studies disprove this theory by showing that the 3' UTR influences other genes in addition to the mRNA through genetic networks. Attempts to isolate genes involved in muscle-cell differentiation prompted the search for genes that could complement the defect by introducing cloned DNAs from differentiating cells. The DNAs isolated by the study were the 3 inch UTRs of mRNAs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation
Article Abstract:
The polyadenylation of c-mos messenger RNA is a vital regulatory step in meiotic maturation of frog oocytes. The restriction of maturation is possible by selective amputation of polyadenylation signals from c-mos mRNA. Functioning of the polyadenylation signals occur in the prosthetic RNAs and restores maturation when linked to c-mos by base pairing. In trans, translation can be stimulated by a RNA possessing cytoplasmic polyadenylation signals.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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