Structure of a transiently phosphorylated switch in bacterial signal transduction

Article Abstract:

It has been possible to obtain the first detailed insight into the conformational changes that take place upon phosphorylation (activation) of a receiver domain. This research has focused on the phosphorylated receive domain of the bacterial enhancer-binding protein nitrogen regulatory protein C. The mechanisms that prompt phosphorylation-dependent activation of mammalian and yeast glycogen phosphorylases differ, but the final outcome - a change in the subunit interface - is similar.

Phosphorylation

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WntD is a feedback inhibitor of Dorsal/Nf-(sub kappa)B in Drosophila development and immunity

Article Abstract:

A study is conducted to show that WntD acts as a feedback inhibitor of the Nf-(sub kappa)B homologue Dorsal during both embryonic patterning and the innate immune response to infection. Results describe the first secreted feedback antagonist of Toll signaling, and demonstrate a novel Wnt activity in the fly.

Science & research, Psychological aspects, Drosophila, Inhibition, Inhibition (Psychology)

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