Role of Rel/NF-kappa-B transcription factors during the outgrowth of the vertebrate limb

Article Abstract:

There is a common signalling process mediating the activity of Rel/NF-kappa-B in both Drosophila and vertebrate development. This finding will form the basis for further work in identifying possible mechanisms through which Rel/NF-kappa-B proteins could regulate cell proliferation during limb development. It has been established that Rel/NF-kappa-B transcription factors are involved in vertebrate limb development, but some other factor or factors expressed in the limb primordia are likely to cooperate with Rel/NF-kappa-B in determining limb outgrowth.

Genetic regulation

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Transcriptional activation by BRCA1

Article Abstract:

The binding of the carboxy-terminal part of BRCA1 to GAL4 DNA-binding domain leads to a transcriptional transactivation activity. This activation is absent in four distinct BRCA1 mutations in families predisposed to ovarian and breast cancer. This indicates the role played by BRCA1 gene in the mechanism of tumour suppression. Among families with BRCA1-linked predisposition for ovarian and breast cancer, more than 134 mutations in BRCA1 have been found.

Causes of, Physiological aspects, Gene mutations, Gene mutation, Observations, Cancer, Disease susceptibility

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