Running without regulators
Article Abstract:
No master-regulator gene able to commit a cell to being a muscle cell has yet been identified. The two most likely candidates, MyoD and Myf-5, have been discounted because recent work shows that muscle can form when both are absent. Neither are the members of the myogenic helix-loop-helix (mHLH) transcription factor family viable candidates, as they have been shown to be expressed in frog and nematode cells that are not myogenic. Perhaps researchers should concentrate on discovering the location of nodes, rather than the identity of nodal master-regulators.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Oncogene ect2 is related to regulators of small GTP-binding proteins
Article Abstract:
A BALB/MK mouse keratinocyte expression cDNA library was screened for transforming potential to fibroblasts, resulting in the isolation of a gene designated ect2. The transforming function of ect2 was activated upon truncation of the N-terminal region of the normal product. Sequence comparisons showed that the Ect2 protein is similar to members of a family of Rho-like small GTP-binding proteins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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