Salt-resistant hypertension in mice lacking the guanylyl cyclase-A receptor for atrial natriuretic peptide
Article Abstract:
Disruption of the guanylyl cyclase-A (GC-A) receptor gene causes a chronic increase in blood pressure and affects peripheral resistance in mice fed on a normal salt diet. Atrial natriuretic peptide (ANP) combines with GC-A in the kidney to regulate natriuresis and diuresis. GC-A effects the vasculature level, independent of salt concentration. ANP enhances sodium excretion, reduces blood pressure and increases the concentration of c-GMP.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Swimming with sperm
Article Abstract:
Issues concerning research connecting calcium ion channels to sperm mobility and to ways of increasing levels of fertility are discussed. Particular attention is given to analyses of sperm movements and to extracellular information processed by sperm cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor
Article Abstract:
Research is presented concerning the secretion of atrial natriuretic peptide hormone by the heart as a response to blood pressure increases. The crystalline structure of the glycosylated dimerized hormone-binding domain dimer is described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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