Scientists rethink approach to HIV gels

Article Abstract:

The failure of a candidate microbicide gel in large clinical trials has highlighted that scientists should change their approach to combat the HIV epidemic. The U.S. National Institutes of Health's Office of AIDS Research has set up a working group on microbicides that is expected to solicit advice from independent experts about which products should proceed to clinical trials.

United States, HIV infection, Drug therapy, HIV infections

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Robust Salmonella metabolism limits possibilities for new antimicrobials

Article Abstract:

In vivo information about over 700 Salmonella enterica enzymes from network analysis of mutant phenotypes, genome comparisons and Salmonella proteomes from infected mice are obtained. The comprehensive in vivo analysis suggests a shortage of new metabolic targets for broad-spectrum antibiotics, and draws attention to the previously known but unexploited targets.

Physiological aspects, Genetic aspects, Microbial metabolism, Salmonella

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Starting to gel

Article Abstract:

There is an urgent need for microbicides that are creams or gels that can help women prevent HIV infection. The first round of large-scale trials on microbicide research getting underway will prove to be a boon for millions of African young women.

Africa, Usage, Women's health, AIDS (Disease)

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