Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
Article Abstract:
The human cytomegalovirus (HCMV) genome encodes proteins that are transferred from the endoplasmic reticulum (ER) to the proteasome for destruction, the process involving Sec61 complex. The HCMV gene US2 specifies a product that induces synthesized major histocompatibility complex (MHC) class I molecules to be transported from the ER into the cytosol where they are deglycosylated. The deglycosylated breakdown intermediate is associated with the Sec61 complex, showing that retrograde transport occurs. After deglycosylation, they are degraded by the proteasome.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
Article Abstract:
An important physiological adaptation to endoplasmic reticulum(ER) stress is the elimination of misfolded proteins from the ER by retro-translocation. The identification of a membrane protein complex that provides the link to the process is reported.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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