Sickly channels in mild disease
Article Abstract:
Cystic fibrosis is caused by a defective epithelial Cl- channel, the cystic fibrosis transmembrane regulator (CFTR). The most common mutation on the CFTR gene involves deletion of F508 in one of the two nucleotide-binding domains. Three less common mutations that lead to mild forms of the disease have also been studied. These involve missense mutations each altering a different arginine residue. However, it was found that the clinically severest mutant CFTR gene is much more prevalent than the less harmful variants. It is speculated that a deficiency in epithelial fluid secretion would ameliorate the severity of dehydration due to enterotoxin-slicited diarrhea.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Cuddling up to channel activation
Article Abstract:
An innovative technique allows researchers to analyse the functions of an allosteric membrane protein and the behaviour of a single cyclic nucleotide-gated ion channel. The experiment also shows the effects of ligands locked onto the channel's four identical cGMP-binding sites. Results of the study are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Shake, rattle or roll?
Article Abstract:
A remarkable property of the voltage sensor that sharpens one's view of its transmembrane movement is described. The controversy regarding the movement of the voltage sensor is also discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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