Signal peptide peptidase is required for dislocation from the endoplasmic reticulum
Article Abstract:
The interacting partners of wild-type US2 are compared with those of a dislocation-incompetent US2 mutant and the signal peptide peptidase (SPP) is identified as a partner for the active form of US2. A decrease in SPP levels by RNA-mediated interference inhibits heavy-chain dislocation by US2 and not by US11.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
A lipid-based model for the creating of an escape hatch from the endoplasmic reticulum
Article Abstract:
A model is described for the involvement of lipid rearrangements in the execution of crucial steps in glycoprotein quality control. This lipid-based model has helped in creating an escape route from the endoplasmic reticulum (ER).
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
A membrane protein requires for dislocation of misfolded proteins from the ER
Article Abstract:
The protein Derlin-1 is essential for the degradation and dislocation of misfolded proteins from the endoplasmic reticulum. The protein is identified through an affinity approach.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Quality control in the endoplasmic reticulum protein factory. Protein folding and misfolding
- Abstracts: Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
- Abstracts: Hitting the sweet spot. Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway
- Abstracts: Global estimate of aerosol direct radiative forcing from satellite measurements. Observational evidence of a change in radiative forcing due to the indirect aerosol effect
- Abstracts: Infectious tumour cells. Evolution of indirect reciprocity. Prisoners of the dilemma