Structural basis for self-association and receptor recognition of human TRAF2

Article Abstract:

The crystal structures of the tumour necrosis factor (TNF)-receptor-associated factor (TRAF) domain of human TRAF2 have been determined, alone and in complex with a TNF receptor-2 peptide, in order to analyze the molecular basis of TRAF self-association and receptor interaction. It has been shown that the TRAF domain of TRAF2 could be a constitutive trimer and binds the receptor peptide without substantial conformational changes. However, it is still possible that receptor-induced TRAF oligomerization or conformational change is the initiator of downstream events.

Tumor necrosis factor, Transduction, Transduction (Genetics)

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Table-top picosecond sources

Article Abstract:

X-ray diffraction is a widely used diagnostic tool in science, determining material structures. Most studies provide information on the static structure, but there is interest in ultra-short x-ray pulses to observe evolving electron density of structures as they change. Rose-Petruck and colleagues have generated picosecond bursts of copper Kalpha radiation, through the irradiation of thin copper wire using a short-pulse high-power laser. This radiation can then measure the response of gallium arsenide crystal to sudden heating.

X-rays, X-ray diffraction, Laser pulses, Ultrashort, Ultrashort laser pulses

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Sources of variations in patterns of plant-insect association

Article Abstract:

Parasitic insects' dietary preferences evolve through interaction between the parasites and host plant species of varying acceptability as food. Populations of the nymphaline butterfly (Euphydryas editha) and two plants that it parasitizes, Penstemon rydbergii and Collinsia parviflora, were studied to find out whether insect preference or plant acceptability dominated the parasite-host relationship. The two factors, both of which are genetic in origin, act together to cause diet to evolve separately.

Models, Insects, Insect-plant relationships, Plant parasites, Host plants

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