Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA
Article Abstract:
The single-stranded-DNA-binding domain of human replication protein A (RPA) bound to DNA is composed of two structurally homologous subdomains. The single-stranded DNA (SSDNA) is found in a channel that runs across both subdomains. The structure of each RPA70 subdomain is similar to the structure of bacteriophage single-stranded-DNA-binding proteins. RPA70 is the largest subunit that binds to SSDNA and mediates interactions with cellular and viral proteins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Crystal structure of the CorA M[g.sup.2+] transporter
Article Abstract:
The CorA family of magnesium transporters is the primary M[g.sup.2+] uptake system of most prokaryotes and a functional homologue of the eukaryotic mitochondrial magnesium transporter. The crystal structures of the full-length Thermotoga maritima CorA in an apparent closed state and its isolated cytoplasmic domain at 3.9 Angstrom and 1.85 Angstrom resolution, respectively is determined.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism
Article Abstract:
The structures of human insulin-degrading enzyme (IDE) in complex with four substrates (insulin B chain, amyloid-beta peptide (1-40), amylin and glucagon) are reported. The molecular basis for substrate recognition and allosteric regulation of IDE might help in designing IDE-based therapies to control cerebral amyloid-beta and blood sugar concentrations.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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