Subunit arrangement and function in NMDA receptors

Article Abstract:

Neurotransmission mediated by N-methyl-D-aspartate (NMDA) receptors with respect to their NR1 and NR2 subunits is studied and the crystal structures of the ligand-binding core of NR2A with glutamate and that of the NR1 and NR2A heterodimer with glutamate and glycine are reported. Analysis of the heterodimer interface using biochemical and electrophysiological experiments confirms that the NR1-NR2A heterodimer is the functional unit in tetrameric NMDA receptors.

Glutamate, Ligand binding (Biochemistry), Neural transmission, Synaptic transmission, Methyl aspartate, N-methyl-D-aspartate, Structure, Chemical properties

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Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

Article Abstract:

The mechanism of binding of three antidepressant, clomipramine, desipramine and imipramine to LeuT, a prokaryotic homologue of mammalian neurotransmitter sodium symporters, is studied. Results show that the drugs bind noncompetitively to an extracellular facing vestibule to inhibit substrate release.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Antidepressant Preparations, Health aspects, Antidepressants, Binding sites (Biochemistry), Active sites (Biochemistry), Neurotransmitters

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Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

Article Abstract:

The low-pH crystal structure of a chicken acid-sensing ion channel 1 deletion mutant at 1.9-angstrom resolution is described. The proton activation in one of the carboxyl domains of the subunits changes the crystal structure.

Lattice dynamics, Mutation (Biology), Mutation, Ion channels, Carboxyl compounds, Report

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