Suppression with a difference
Article Abstract:
Two research teams report that the well-characterized protein kinase PKR (RNA-activated protein kinase) is a tumor suppressor. This enzyme is present at low levels constitutively in many cell types and may be interferon induced. PKR is known to be involved in the anti-viral activity of interferons. In 1990 the complementary DNA for human PKR was cloned and research promises to reveal a heretofore unknown tumor suppressor activity, to tie this in with explanation of the anti-viral activity of interferons and to explain the role of inactivation of endogenous PKR by certain viral gene products.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A
Article Abstract:
Experimental studies on Drosophila eye reveal that precise spatial regulation of dpp expression during eye development requires the catalytic subunit of cyclic AMP-dependent protein kinase A (Pka-C1). An ectopic morphogenetic wave having premature ectopic photoreceptor differentiation and non-autonomous propagation of dpp expression is generated by the loss of Pka-C1 function. A signaling pathway that regulates the orderly temporal progression of differentiation across the eye imaginal disc has Pka-C1.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine
Article Abstract:
The treatment with the cyclin-dependent kinase (CDK) inhibitor (R)-roscovitine has yielded effective arrest of cystic disease in jck and cpk mouse models of polycystic kidney diseases (PKDs). The results have shown that inhibition of CDK is a new and effective approach to the treatment of PKD.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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