Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination
Article Abstract:
The conversion of immature to mature dendritic cells is accompanied by a marked cellular reorganization including the redistribution of major histocompatibility complex class II molecules (MHC II) from late endosomal and lysosomal compartment to plasma membrane. It is found that the MHC II [beta]chain cytoplasmic tail is ubiquitinated in mouse immature dendritic cells, thus dendritic cells exhibit a unique ability to regulate MHC II surface expression by selectively controlling MHC II ubiquitination.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Phytochrome signalling is mediated through nucleoside diphosphate kinase 2
Article Abstract:
Nucleoside diphosphate kinase 2 (NDPK2) is shown to be an upstream part of the phytochrome signalling pathway in Arabiodopsis thaliana. NDPK acts as a tumor suppressor in animal and human cells. Recombinant NDPK2 in Arabiodopsis was found to preferentially bind to the red-light-activated form of phytochrome and tha the activity of recombinant NDPK2 is increased by the interaction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Surface ozone depletion in Arctic spring sustained by bromine reactions on aerosols. Ideas flow on Antarctic vortex
- Abstracts: Superexpansive gels. Voltage-sensitive magnetic gels as magnetic resonance monitoring agents
- Abstracts: Formulation of a Roman cosmetic. Demonstration of an all-optical quantum controlled-NOT gate. A polymer/semiconductor write-once read-many-times memory
- Abstracts: Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala. Dopamine as chicken and egg
- Abstracts: Structure of a transiently phosphorylated switch in bacterial signal transduction. WntD is a feedback inhibitor of Dorsal/Nf-(sub kappa)B in Drosophila development and immunity