Systems biology approaches identify ATF3 as a negative regulator of toll-like receptor 4
Article Abstract:
A comprehensive set of transcriptomic data derived from Toll-like receptor (TLR)-activated macrophages was analyzed to identify a prominent group of genes that appear to be regulated by activating transcription factor 3 (ATF3), which is a member of the CREB/ATF family of transcription factors. It was observed that ATF3 is itself induced by lipopolysaccharide, which seems to regulate TLR-simulated inflammatory responses, as part of a negative-feedback loop.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Toll gates for pathogen selection
Article Abstract:
Research by D. M. Underhill and others indicates into TLR2 and the TLR4 mammalian Toll-like receptors indicates that just as in the Drosophila melanogaster, there are two different receptors which differentiate between microbial pathogens or products of them. TLR2 plays a major role in responses to microbial pathogen such as Gram-positive bacteria and TRL4 participates in the recognition of lipopolysaccharide and Gram-negative bacteria.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Toll-like receptors in the induction of the innate immune response
Article Abstract:
The role of the Toll or Toll-like family of receptor proteins in the induction of the innate immune response to infectious disease is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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