Targeting of non-Ig sequences in place of the V segment by somatic hypermutation
Article Abstract:
An immunoglobulin V(sub k) segment replacement by human beta-globulin or prokaryotic neo or gpt genes causes no alteration in the rate of hypermutation in mice containing single or multiple transgene constructs. These findings indicate that the V segment is not essential to hypermutation, that it provides no unique sequences and that a heterologous non-immunoglobulin sequence is just as efficient in somatic hypermutation as an immunoglobulin sequence.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA
Article Abstract:
Research shows that cytidine deaminase CEM15 can induce guanine to adenine hypermutation in newly synthesized HIV-1 replicating viral genome. Data indicate that this mutation mechanism appears to be the viral defence mechanism in host cells. Furthermore, accumulation of CEM-15 non-lethal hypermutation can lead to genetic variation of primate lentiviral populations.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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The genetic basis for skeletal diseases
Article Abstract:
This review discusses the skeletal diseases with respect to classification, disorders of bone and cartilage cell differentiation, and osteochondrodysplastic growth-plate defects. Research shows that the normal development of bones involves many transcription factors and signalling pathways and that mutations in the patterning genes lead to growth disorders.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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