The APC/C and CBP/p300 cooperate to regulate transcription and cell cycle progression
Article Abstract:
The anaphase promoting complex/cyclosome(APC/C) is a multicomponent E3 ubiquitin ligase which by targeting protein substrates for 26S proteasome-mediated degradation through ubiquitination coordinates the temporal progression of eukaryotic cells through mitosis and the subsequent G1 phase of the cell cycle. The results define discrete roles for the APC/C-CBP/p300 complexes in growth regulation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis
Article Abstract:
The predictive value of molecular machine models that are involved in Caenorhabditis elegans early embryogenesis is examined. An integrated gene/protein network generated from functional relationship of protein interaction, expression profiling similarity and phenotypic profiling similarity is useful for the derivation of molecular machine models.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
Article Abstract:
Research reveals that BTB proteins are combination of the functional properties of Skp1 and F-box proteins in a single polypeptide. Data indicate that BTB-domain proteins serve as substrate-specific adaptors for Caenorhabditis elegans CUL-3 protein.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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