The CBP co-activator is a histone acetyltransferase
Article Abstract:
The functional activity of the transcriptional co-activator CBP protein, was investigated using immunoprecipitation-histone acetyltransferase (IP-HAT) assay. The results confirmed that the protein possesses HAT activity and that its HAT domain is adjacent to the binding site for the transcriptional activator E1A. It was also deduced from the findings that E1A, as an activator of transcription, functions via a mechanism wherein the CBP-associated HAT activity is targeted to its specific promoters.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Retinoblastoma protein recruits histone deacetylase to repress transcription
Article Abstract:
Histone deacetylase activity is ascribed to HDAC1 and HDAC2, mammalian proteins, existing in a complex with other proteins, and are implicated in transcriptional repression due to nucleosome remodelling. Rbp48, a known Rb-binding protein, is found in the deacetylase complex, and an investigation was undertaken to determine if the Rb repressor is linked to histone deacetylase activity, and results indicated its association with deacetylase activity in vivo.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
Article Abstract:
Research is presented concerning the ability of the histone H3 which has been methylated at lysine 9 to bind with the heterochromatin protein. The gene silencing activity of heterochromatin proteins in Drosophila is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The post-spinel transformation in Mg2SiO4 and its relation to the 600-km seismic discontinuity. Deeper understanding
- Abstracts: Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
- Abstracts: Beta-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18
- Abstracts: Engineering a broken heart. Congenital heart disease in mice deficient for the DiGeorge syndrome region. Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice