Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
Article Abstract:
Rb-deficient embryos carry profound abnormalities of fetal liver macrophages that prevent physical interactions with erythroblasts but in contrast, wild-type macrophages bind Rb-deficient erythroblasts and lead them to terminal differentiation and enucleation. Rb has a cell autonomous function in fetal liver macrophages, and restrains Id2 in these cells in order to implement definitive erythopoiesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Degradation of ld2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
Article Abstract:
Id2, inhibitor of DNA- binding 2, is shown to interact with the core subunits of APC/C and Cdh1 in primary neurons. AC/[C.sup.Cdh1] initiates a chain of events by setting the timing of Id protein degradation in the nervous system, which terminates with the activation of downstream targets of bHLH transcription factors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
Article Abstract:
Research is presented concerning the influence of Id proteins in the coordination of cell differentiation and proliferation in mice. The dominant-negative antagonist features of Id2 are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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