The complex language of chromatin regulation during transcription
Article Abstract:
The influence of chromatin on gene regulation is understood by examining the observations that DNA methylation or histone modification is dynamic, and that the presence of certain modifications might not indicate a unique regulatory status. It is shown that fully reconstituted chromatin templates bearing recombinant histones and DNA that are modified in certain ways will provide the ultimate template for understanding their effects on stages of transcription.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Gene network shaping of inherent noise spectra
Article Abstract:
The noise frequency content in growing culture of Escherichia coli is measured and the link between gene circuit structure and noise spectra by demonstrating the negative auto-regulation-mediated spectral shifts is verified. The results revealed that the noise spectral measurement provides mechanistic insights into gene regulation, as perturbations of gene circuit parameters are discernible in the measured noise frequency range.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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An excitable gene regulatory circuit induces transient cellular differentiation
Article Abstract:
Quantitative fluorescence time lapse microscopy is used to observe the activities of multiple circuit components simultaneously in individual cells and the resulting data is analysed in terms of a mathematical model. It is found that an excitable core module containing positive and negative feedback loops explains both entry and exit from the competent state, providing an ideal mechanism for competence regulation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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