The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein
Article Abstract:
Neurons from proliferative zones migrate to their functional sites in the development of the central nervous system. Research demonstrates that the cerebellum of both the homozygotes of rostral cerebellar (rcm) malformation mutation and a newly identified transgenic insertion allele in the mouse is smaller with fewer folia. The rcm complementary DNA was cloned, encoding a transmembrane receptor of the immunoglobulin superfamily. Results show that the rcm protein is similar to the Caenorhabditis elegans (UNC-5) protein, and conclude that UNC5-like proteins could be functional in mediating netrin-guide migration.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
Article Abstract:
The development of thymocytes is a sequential process, and positive thymocyte selection occurs before and independently of negative selection. The positive and negative selection take place in distinct anatomical sites. In mice expressing class II major histocompatibility complex only on the thymic cortex, CD4+ cells are positively selected but clonal deletion fails to occur. The keratin 14 CD4 cells are autoreactive and they make up 5% of the peripheral CD4 T cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line
Article Abstract:
Thymic major histocompatibility complex-B (MHC-B) may affect B-reactive T cells. This was investigated, along with the ability of thymic epithelial cell (TEC) lines to generate cytotoxic T-lymphocytes (CTLs) when injected into bone marrow chimeras of the thymus. One TEC line succeeded in selecting CTLs specific to vesicular stomatitis virus and influenza antigens.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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