The physical basis of how prion conformations determine strain phenotypes

Article Abstract:

An analytical model is presented and experimentally verified to describe the way the dynamic interactions among the effects of prion dilution, competition for a limited pool of soluble protein, and conformation-dependent differences in prion growth and division rates determine the yeast [[PSI.sup.}] strain phenotypes. Analysis reveals that the tendency of yeast Sup35 (the [PSI.sup.}] protein determinant) aggregates to undergo breakage, thus generating seeds, probably determines their physiological impact for both infectious (prion) and non-infectious amyloids.

User Contributions:

Comment about this article or add new information about this topic:

Public Comment:  (50-4000 characters)

Name:

E-mail:

Type the code shown:

Show my email publicly:

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

Article Abstract:

Tandem affinity purification was used to process 4,562 different tagged proteins of the yeast Saccharomyces cerevisiae to provide insight into protein function. Among 4,087 different proteins identified with high confidence by mass spectrometry from 2,357 successful purifications, the results confirmed 7,123 protein-protein interactions for 2,708 proteins in the core data set.

User Contributions:

Comment about this article or add new information about this topic:

Public Comment:  (50-4000 characters)

Name:

E-mail:

Type the code shown:

Show my email publicly:

• Abstracts: The skins of fashion. Moose matters. Pandemonium
• Abstracts: The influence of sensory information on patch residence time in wolf spiders (Araneae: Lycosidae). Wolf spider predator avoidance tactics and survival in the presence of diet-associated predator cues (Araneae: Lycosidae)
• Abstracts: Global analysis of protein phosphorylation in yeast. Timing the machine. The BTB protein MEL-26is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase
• Abstracts: Chinese law aims to quell fear of failures. Accommodating dissent
• Abstracts: True paternal care in a multi-male primate society. Sexual selection in wild baboons: from mating opportunities to paternity success