Global analysis of protein phosphorylation in yeast
Article Abstract:
The biochemical understanding of protein phosphorylation on a global scale is extremely limited and half of the yeast kinases have known in vivo substrates and the phosphorylating kinase is known for less than 160 phosphoproteins. The phosphorylation results are assembled into a first generation phosphorylation map for yeast since many yeast proteins and pathways are conserved and insights are provided into the mechanisms and roles of protein phosphorylation in many eukaryotes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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The BTB protein MEL-26is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase
Article Abstract:
Research points out that BTB-containing proteins may serve as substrate-specific adaptors in Cul3-based E3-ubiquitin ligases. Data show that MEL-26, a BTP-containing protein, participates in the degradation of MEI-1, specifically interacts with CUL-3 and MEI-1, and exhibit substrate-specific adaptor properties.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Timing the machine
Article Abstract:
Experiments showed that the key part of the cell division process is timed by a common cellular control device called protein phosphorylation. Experiments also showed that ZEN-4MKLP1 necks could be dephosphorylated due to CDC14.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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