Toll-like receptor signaling in macrophages links the autophagy pathway to phagocytosis
Article Abstract:
The correlation between the toll-like receptor (TLR) engagement activates multiple defence mechanisms inside phagocytes, inclusive of facilitation of phagosome masturation and autophagy is analyzed. It is demonstrated that a particle that includes TLRs on a murine macrophage while it is a phagocytosed initiates the autophagosome marker LC3 to be quickly used to the phagosome in a way depending on the autophagy pathway proteins ATG5 and ATG7 and this process come after recruitment of beclin 1 and phosphoinositide-3-OH kinase activity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes
Article Abstract:
Two chaperones designated as proteasome assembling chaperone-1 (PAC1) and PAC2, are involved in maturation of mammalian 20S proteasomes. PAC1 and PAC2 associate themselves as heterodimers with proteasome precursors and are degraded after formation of the 20S proteasome is completed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Loss of autophagy in the central nervous system causes neurodegeneration in mice
Article Abstract:
The loss of autophagy-related 7 (Atg7), a gene necessary for autophagy, will lead to neurodegeneration. The results show that autophagy is essential for the survival of neural cells and its impairment is entailed in the pathogenesis neurodegenerative disorders.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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