Transporter-independent processing of HIV-1 envelope protein for recognition by CD8+ T cells
Article Abstract:
An analysis shows that the transportation of cytosolic peptides into the endoplasmic reticulum for a connection with class I molecules is necessary and may involve a heterodimer of the MHC-encoded proteins, Tap-1 and Tap-2 12-17. The analysis is based on the theory that CD8 cytolic T lymphocytes (CTT) determine virally infected cells by identifying processed viral antigen associating with class I major histocompatibility complex (MHC) molecules on infected cells. Results reveal that the HIV-1 envelope (env) protein in infected cells is processed by a new Tap-1/Tap-2 independent pathway that is localized to the endoplasmic reticulum.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Moving in mysterious ways
Article Abstract:
Five papers addressing the vital process of chemotaxis have the main message that chemotaxis needs the phosphoinositide-3-OH kinase (PI(3)K) enzyme to generate lipid signals that lead to polarized signalling cascade in the cell. Three of the papers describe the use of knockout mice without the catalytic subunit of PI(3)Kgamma, p110gamma.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration
Article Abstract:
It has been established that DOCK2, a haematopoietic cell-specific CDM family protein, is vital for lymphocyte chemotaxis. However, DOCK2 deficiency does not influence the chemotactic response of monocytes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Attractiveness of scents varies with protein content of the diet in meadow voles. The response of native Australian rodents to predator odours varies seasonally: a by-product of life history variation?
- Abstracts: Swifter, higher, stronger: pushing the envelope of performance. Nobel goes to T-cell pioneers whose work 'changed face of immunology.'
- Abstracts: Estimating fat content of caribou from body condition scores. Habitat use by female caribou: Tradeoffs associated with parturition
- Abstracts: A pigment-binding protein essential for regulation of photosynthetic light harvesting. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
- Abstracts: Training idiot savants: the lack of human dimensions in conservation biology. Conservation biology and western religious teachings