Triggers for channel opening
Article Abstract:
Chemical signaling in the brain involves the rapid opening and closing of channels known as ligand-gated ion channels, which lie in the membranes of nerve cells. A pathway by which changes at the ligand-binding site is propagated to its channel region is revealed, a proline residue that acts as a molecular switch to control channel opening is identified and the theory on the ion channels opening and closing in response to binding neurotransmitter is proposed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Structure of the Sec13/31 COPII coat cage
Article Abstract:
A three-dimensional reconstruction of the Sec13/31 cages at 30-Angstrom resolution reveals a novel cuboctahedron geometry with the potential to form a flexible lattice and to generate a diverse range of containers. The data are consistent with a model for COPII coat complex assembly in which Sec23/24 has a non-structural role as a multivalent ligand localizing the self-assembly of Sec13/31 to form a cage lattice driving ER cargo export.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Argos inhibits epidermal growth factor receptor signalling by ligand sequestration
Article Abstract:
An investigation was conducted for showing that Argos inhibited Drosophila EGFR (DER) signalling without directly interacting with the receptor but they inhibited DER signalling by sequestering the DER-activating ligand Spitz. The result indicates that the Argos is capable of efficiently blocking the initiation of DER activation by Spitz but it is not capable of reversing DER activation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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