Tropism switching in Bordetella bacteriophage defines a family of diversity-generating retroelements
Article Abstract:
Bordetella bacteriophages generate diversity in a gene that specifies host tropism. This micro evolutionary adaptation is produced by a genetic element that combines the basic retro element life cycle of transcription, reverse transcription and integration with site-directed, adenine-specific mutagenesis. Using the Bordetella phage cassette as a signature, numerous related elements in diverse bacteria are identified, constituting a new family of retroelements with the potential to confer selective advantages to their host genomes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Efficient integration of an intron RNA into double-stranded DNA by reverse splicing
Article Abstract:
Reverse splicing is an efficient way of integrating an intron RNA into double-stranded DNA. The group II intron, aI1, encodes an analogous endonuclease specific for a target site compatible with the different exon-binding sequences of the intron RNA. Direct integration of linear intron RNA into DNA occurs as most of the aI1 undergoes reverse splicing in vitro. Agarose gels and the use of DNA substrates individually labelled enable the characterization of the products of reverse-splicing reaction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Somatic stem cell niche tropism in Wolbachia
Article Abstract:
Wolbachia are intracellular bacteria found in the reproductive tissue of all major groups of arthropods and are transmitted vertically from the female hosts to their offspring, in a pattern analogous to mitochondria inheritance. A demonstration that newly introduced Wolbachia cross several tissues and infect the germline of the adult Drosophila melanogaster female is presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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