Typing prion isoforms
Article Abstract:
The pathogenesis of prion diseases is centered on the conversion of the cellular prion protein (PrP(supra C)) into the pathological and protease-resistant isoform (PrP(supra res)). The conversion results in PrP (supra res) types that have distinct physical and chemical characteristics. An observation of the types of PrP (supra res) in sporadic Creutzfeldt-Jakob disease, iatrogenic CJD (iCJD), and the new variant CJD (vCJD) shows that iCJD and vCJD reveals only two patterns of electrophoretic mobility.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Prion (PrPSc)-specific epitope defined by a monoclonal antibody
Article Abstract:
Research shows that the monoclonal antibody 15B3 recognizes disease-specific forms of the ubiquitous cellular prion protein PrP(super C). Scientists believe that 15B3 will be useful in establishing a technique to diagnose transmissible spongiform encephalopathies (TSEs). TSEs including Creutzfeldt-Jakob disease are hard to diagnose using current techniques. The PrP(super Sc)-specific epitope molecule is described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Antibodies inhibit prion progagation and clear cell cultures of prion infectivity
Article Abstract:
Research is presented describing the study of degenerative brian diseases and the use of antibodies to cure prion infections which are pathogenic agents.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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