VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model
Article Abstract:
Vascular endothelial growth factor, VEGF 'knock in' mice, in which the hypoxia response element sequence in VEGF promoter was deleted, have an impaired potential to upregulate VEGF levels in conditions of stress, and these mice develop ALS like neuropathology. The results obtained, using behavioral and anatomical outcomes are that, an Equin infectious anemia virus (EIAV) lentiviral vector expressing VEGF induces a substantial increase in survival in a clinically relevant ALS model.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Signalling silenced
Article Abstract:
The scientists discuss the mechanisms used by matrix metalloproteinase tissue inhibitor-2 protein to inhibit blood-vessel formation. They suggest that these mechanisms can be used for cancer treatment via cutting off its blood supply.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Creating unique blood vessels
Article Abstract:
Issues are presented concerning the physiological processes governing the release of molecules by tissues suffering a shortage of oxygen. The function of these molecules in the growth of blood vessels is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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