Vesicle assembly in microtubes
Article Abstract:
Microtubular structures composed of synthetic oligocine-based bola-amphiphiles enclose vesicles in non-covalent self-assembly. The bola-amphiphiles are dicarboxamides with two oligoglycine head groups at each end. Pronounced tube-like fibre structures with several vesicular assemblies were seen using phase-contrast microscopy. These tube structures were seen to coexist with spherical and ellipsoidal vesicles inside them, using video-enhanced dark-field microscopy. Smaller spherical vesicles were noted around their ends. No vesicles were seen in the external surrounding aqueous medium.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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New cytoskeletal liaisons
Article Abstract:
Mounting evidence that microtubules and actin microfilaments have similar roles and constituents in eukaryotic cells received further support from the work of two research groups. Working separately, the two groups found a new form of actin linked to the microtubule system. James P. Lees-Miller and colleagues showed that the new actin is part of the dynactin complex that stimulates dynein-controlled organelle transport, while Sean W. Clark and David I. Meyer showed that the new actin is part of the centrosome, the cellular structure that organizes the microtubules.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine
Article Abstract:
Escherichia coli pathogens are responsible for a wide number of diseases, including kidney infection and diarrhoea. The enteropathogenic (CNF2) and uropathogenic (CNF1) strains of E. coli cause diseases in animals and humans respectively and produce the virulent toxins designated cytotoxic necrotizing factors (CNF). Studies show that CNF1 deamidates a glutamine residue at position 63 of Rho resulting in the constitutive activation of Rho and inducing the actin stress fibres to reorganize.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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