Was HIV present in 1959?
Article Abstract:
The detection of gag sequences of human immunodeficiency virus type 1 (HIV-1) from the tissue of a 25-year old man who died mysteriously in 1959 in Manchester, England, has raised the possibility that the man had AIDS. George Williams, who had earlier treated the man suffering from pneumonia and perioral and perianal herpes, examined the tissues using polymerase chain reaction technology. Gerald Corbitt of the University of Manchester detected HIV in kidney, bone marrow, spleen and pharyngeal mucosa tissue of the man but not in the tissue of a control also from 1959.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Decay characteristics of HIV-1-infected compartments during combination therapy
Article Abstract:
The concentration of human immunodeficiency virus type 1 virus (HIV-1) in infected humans drops in a phased manner during combination therapy. The second phase is much longer than the first and appears to be dominated by the decay of infected cells rather than revitalization of the immune system. Decay characteristics are discussed. Calculations indicate that the HIV-1 virus would take between 2.3 and 3.1 years to be totally eradicated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
Article Abstract:
The CD4 lymphocyte count increases considerably while the plasma HIV-1 level decreases exponentially when HIV-infected patients are treated with the HIV-1 protease inhibitor, ABT-538. HIV-1 replication within the body is rapid and productive since the minimum estimates for the clearance and production of HIV-1 and the CD4 turnover is high. This indicates that HIV-1 increases in the body by destroying CD4 lymphocyte cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
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