Nodal signalling in vertebrate development
Article Abstract:
A signalling pathway centered on Nodal, a transforming growth fact Beta-related signal, may be responsible for certain events that configure the vertebrate embryo. Nodal signals activity is controlled extracellularly by EGF-CFC cofactors enabling precise control of mesoderm and endoderm formation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Tail of decay
Article Abstract:
The head-to-tail development of vertebrates is described with the help of a mechanism, which is based on gradual decay of a messenger RNA (mRNA) molecule. The resulting gradient is expected to regulate the maturation of cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Zebrafish organizer development and germ-layer formation require nodal-related signals
Article Abstract:
It is reported that the zebrafish squint (sqt) and cyclops (cyc) genes have necessary, but partly redundant, functions in organizer development, and in mesoderm and endoderm formation. The sqt gene encodes a member of the TGF-beta superfamily related to mouse nodal, and cyc encodes another nodal-related protein. Misexpression of sqt RNA in the embryo leads to expanded or ectopic dorsal mesoderm.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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