p73 is a human p53-related protein that can induce apoptosis
Article Abstract:
Cancer research shows that the p73 gene expression induces programmed cell death resulting in inhibited cell growth. The gene, which is located on chromosome 1 of the human genome, is shown to activate the transcription of p53-responsive genes. Mammalian expression plasmids were used to establish p73 function. Experimental techniques involving plasmid construction, immunoprecipitation and western blot analysis and immunofluorescence staining are described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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The last cut is the deepest
Article Abstract:
D.W. Nicholson and his colleagues, and M. Tewari and his colleagues have identified a gene, a cysteine protease called CPP-32, that plays a crucial role in apoptosis. Apoptosis is an innate program by which cells commit suicide controlled by a set of genes. The newly discovered gene, encoding the eponymous interleukin-1beta-converting enzyme (ICE), is the pivotal trigger of cell suicide.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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A receptor for phosphatidylserine-specific clearance of apoptotic cells
Article Abstract:
A gene which recognises phosphatidylserine on apoptotic cells has been cloned and transfected to B and T lymphocytes, which then recognise and engulf apoptotic cells. The protein seems to be expressed on the surface of macrophages, fibroblasts and epithelial cells, suggesting it as a canndidate phosphatidylserine receptor highly conserved throughout phylogeny.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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