A concise peer into the background, initial thoughts and practices of human gene therapy
Article Abstract:
Gene therapy rose rapidly as an intellectual by-product of fundamental discoveries in molecular biology and evolved as a new branch of experimental medicine along with technological advances in genetic manipulation. It is concluded that further improvements in gene transfer technologies and deeper insight in host-vector interactions are guaranteed before clinical gene therapy reaches maturity.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2005
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Is ectopic expression caused by deregulatory mutations or due to gene-regulation leaks with evolutionary potential?
Article Abstract:
A study is conducted in which evidence for ectopic expression and the hypotheses proposed for its origin and evolution is presented. The result shows that ectopic expression might represent a leak in the evolution of regulatory systems, but one that is endowed with considerable evolutionary possibilities.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2005
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A cluster translocation model may explain the collinearity of Hox gene expressions
Article Abstract:
The hypothesis of a cluster translocation model reflecting the collinearity of Hox genes is discussed. The model explains how gene activation is triggered and the different collinearities at the initial stages of gene expression.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2004
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