A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle

Article Abstract:

A forkhead gene, FoxE3, has been shown to be necessary for closure of the lens vesicle and lens epithelial proliferation in eye development. The cloning of this gene, expressed in the lens epithelium, has been carried out. It is mutated in a classic mouse model with ensuing defective lens development. In the mouse mutant dysgenetic lens (dyl) the lens vesicle does not separate from the ectoderm and fusion between lens and cornea results. With no proliferating anterior lens epithelium absence of secondary lens fibers and a dysplastic cataractic lens results.

Finland, Sweden, Research, Usage, Cataract, Epithelial cells, Cytochemistry, Mice, mutant strains, Mutant mice, Cell differentiation, Cell proliferation, Cornea, Cataracts

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The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus

Article Abstract:

Disruption of the Mf1 gene which codes for a forkhead/winged helix transcription factor results in skeletal abnormalities, eye defects and hydrocephalus. This gene is expressed in mesenchymal tissues destined to be cartilages, meninges, periocular tissues, endothelium or kidney. Homozygous null mutation of this gene in mice results in hydrocephalic fetuses containing eye defects. These mice die at birth.

Mice, Mice (Rodents), Hydrocephalus

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