A genetic map of the mouse suitable for typing intraspecific crosses
Article Abstract:
A complete mouse genetic linkage map consisting entirely of simple sequence length polymorphisms (SSLPs) was constructed. Such SSLPs can be easily typed by using the polymerase chain reaction. The map contains 317 SSLPs at an average spacing of 4.3 centimorgans and is detectably linked to about 99% of the mouse genome. Some 50% of the markers are polymorphic in a typical cross between two inbred laboratory strains. The map covers most of the mouse genome, and will prove useful for mouse geneticists. In addition, the SSLPs will be useful for population geneticstudies.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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New molecular markers for the distal end of the t-complex and their relationships to mutations affecting mouse development
Article Abstract:
The t- complex of mouse chromosome 17 contains many genes involved in early or mid- stage embryogenesis. In order to molecularly characterize the t-complex, 17 cosmid clones were obtained that mapped to this region. Twelve of these clones were mapped within the t-complex. Restriction fragment length polymorphism analysis using these clones as probes showed that they will be useful as molecular markers in the characterization of the t-complex. The remaining five clones were mapped to the Leh66b locus in t-haplotypes.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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The proximal end of mouse chromosome 17: new molecular markers identify a deletion associated with quaking
Article Abstract:
Five clones which map to the distal part of mouse chromosome 17, proximal to Leh66D, were used as genetic markers to analyze this region. The results showed that a neurological mutation termed 'quaking' is associated with a deletion detected by one of the clones. The other clones were able to map positions of some members of two low copy number gene families. Additionally, a region of unusually high recombinational activity was detected at the proximal end of chromosome 17.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
User Contributions:
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