A molecular mechanism regulating rhythmic output from the superchiasmatic circadian clock
Article Abstract:
The transcriptional regulation of the clock-controlled neuropeptide arginine vasopressin gene in the suprachiasmatic nuclei (SCN) was investigated to relate the central clock mechanism in circadian biology. It was believed that vasopressin synthesized by SCN neurons was both anatomically and physiologically segmented for specific actions with the central nervous system. In vitro and in vivo studies revealed that the mPer1 transcription was mediated by CLOCK-BMAL1 heterodimers linked to E box enhancers.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Cellular construction of a circadian clock: period determination in the suprachiasmatic nuclei
Article Abstract:
Clock cells are single-cell circadian oscillators found at the suprachiasmatic nucleus. The regulation of circadian rhythm in tau mutant hamsters is investigated by monitoring the firing rate of individual clock cells using fixed multielectrode plates. Tau mutant hamsters exhibit altered circadian rhythms making them ideal for circadian rhythm investigations. Results reveal that the circadian rhythm in these animals is dependent on the average pattern in the firing rates of individual clock cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Posttranslational mechanisms regulate the mammalian circadian clock
Article Abstract:
Research demonstrates the role of a number of posttranslationally modified mouse liver proteins in the regulation of circadian clock. Data show that the proteins undergo phosphorylation, DNA binding, and interactions to maintain, stabilize, and regulatethe mammalian circadian clock.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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