A new role for Glia: generation of neurons!
Article Abstract:
Results of several studies have made it possible to determine at least some multipotent neural stem cells. Enriched neural stem cells can be obtained by isolating ependymal cells or SVZ astrocytes. A critical criteria for stem cell identification in the hemopoietic systems is the ability of the transplanted cells to reconstitute the entire tissue. The identification of neural stem cells promises to promote a new era in studies concerning the workings of neural stem cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Glia-Derived D-Serine controls NMDA receptor activity and synaptic memory
Article Abstract:
The physiological impact of the glial environment on NMDA receptor-dependent activity and plasticity was studied as D-Serine is released exclusively by astrocytes. The degree of astrocytic coverage of neurons governs the level of glycine site occupancy on the NMDA receptor, thereby affecting their availability for activation and thus the activity dependence of long-term synaptic changes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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