Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
Article Abstract:
FoxO forkhead transcription factors are found to act as signal transducers at the meeting point of Smad, P13k and FoxG1 pathways and Smad proteins activated by Tgf-beta, a pleiotropic cytokine, form a complex with FoxO proteins to activate the growth inhibitory gene p21Cip1. Studies suggest that the activity of this network imparts resistance to the TGF-beta mediated cytostasis during the development of the telencephalic neuroepithelium and in glioblastoma brain tumor cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation
Article Abstract:
A study is conducted to show that condensin facilitates the removal of cohesin from chromosomes during the first meiotic division of budding yeast and that this removal is important to dissolve the links between homologs that ensure proper homolog segregation. This provides an example of a functional connection between cohesin and condensin, two different SMC complexes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-(kappa)B signaling
Article Abstract:
Mice lacking Cyld are shown to be highly susceptible to chemically induced skin tumors. Data indicates that, depending on the external signals, Cyld can negatively regulate different NF-(kappa)B pathways, inactivation, while inhibition of Bcl-3 controls proliferation and tumor growth.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Contributions of Boris Ephrussi to the development of somatic cell genetics. On the beginnings of somatic cell hybridization: Boris Ephrussi and chromosome transplantation
- Abstracts: Regulation of chemotactic networks by 'atypical' receptors. Leukocytes on the move with phosphoinositide 3-kinase and its downstream effectors
- Abstracts: Quantitative-PCR assessment of Cryptosporidium parvum cell culture infection. Particle based multidimensional multispecies biofilm model
- Abstracts: Fetal programming: Adaptive life-history tactics or making the best of a bad start? . Fluctuating asymmetry predicts human reactive aggression
- Abstracts: Protein splicing of inteins and hedgehog autoproteolysis: structure, function, and evolution. Bacteriophage-based genetic system for selection of nonsplicing inteins