A phosphatase controls the fate of receptor-regulated Smads

Article Abstract:

One of the long-standing questions in the transforming growth factor [beta] field is answered by identifying a phosphatase, PPM1A that directly dephosphorylates Smad2 and Smad3 to limit their activation. Results reveal that PPM1A affects transcription and biological responses downstream of Smad signaling.

Growth factor receptors

---

PPM1A functions as a Smad phosphatase to terminate TGF[beta] signaling

Article Abstract:

PPM1A/PP2C[alpha] is identified as a bona fide Smad phosphate with the help of a functional genomic approach. It is demonstrated that PPM1A/PP2C[alpha], through dephosphorylation of Smad2/3, plays a critical role in terminating TGF[beta] signaling.

Phosphatases, Genetic research

---

Phy tunes: Phosphorylation status and phytochrome-mediated signaling

Article Abstract:

A type 5 protein phosphatase, PAPP5, which acts on a biologically active phytochrome, increasing its stability and affinity for a downstream signal transducer is studied. It is shown to enhance plant photoresponses.

Protein research, Phytochrome

Similar abstracts:

• Abstracts: Transcriptional checkpoints determining the fate of male germ cells. Homeobox galore: When reproduction goes RHOX and Roll
• Abstracts: Deleterious transposable elements and the extinction of asexuals. How and when did Arabidopsis thaliana become highly self-fertilising
• Abstracts: Distinction at the leading edge of the cell. Kash 'n karry: The KASH domain family of cargo-specific cytoskeletal adaptor proteins
• Abstracts: The three-sided romance of the lateral line: Glia love axons love precursors love glia
• Abstracts: Unbalanced alternative splicing and its significance in cancer. Edit, cut and paste in the nicotinic acetycholine receptor gene family of Drosophila melanogaster

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.