Transcriptional checkpoints determining the fate of male germ cells
Article Abstract:
The production of 100,000,000 sperm cells a day by the human testis relies on a highly coordinated mechanism which regulates cellular replication and differentiation. The luteinizing hormone and follicle-stimulating hormone control the production and differentiation of male germ cells. There are essential transcriptional checkpoints which regulate gene expression in the germ cells undergoing the meiotic cell cycle. The proper transfer of genetic information during the process is ensured by systems which include the ubiquitin mechanism which determines the half-life, stabilization, refolding and translocation of proteins essential for cell physiology.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Homeobox galore: When reproduction goes RHOX and Roll
Article Abstract:
A new homeobox gene cluster composed of genes selectively expressed in reproductive tissues is described. The cluster is found to be on the X chromosome and the genes display a colinear pattern of expression.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium
Article Abstract:
The performance of a cDNA expression screen for the isomerase in bovine retinal pigment epithelium (RPE) is discussed. The isomerase discovered is a previously characterized protein called Rpe65.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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- Abstracts: Intracellular selection, conversion bias, and the expected substitution rate of organelle genes. Simulation study of a multigene family, with special reference to the evolution of compensatory advantageous mutations
- Abstracts: Intracellular selection, conversion bias, and the expected substitution rate of organelle genes. part 2 Biased gene conversion, copy number, and apparent mutation rate differences within chloroplast and bacterial genomes
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