A role for RAD51 and homologous recombination in Trypanosoma brucei antigenic variation
Article Abstract:
Trypanosoma brucei, an African trypanosome that causes sleeping sickness, and its antigenic variation have been studied and a role for RAD51 and homologous recombination found. The variation is useful as an evasion strategy for dealing with immunity, from time to time switching expression of variant surface glycoprotein (VSG) genes. For switching it can change the transcriptional status between an active and an inactive copy of the site of VSG expression or recombination reactions.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
The yeast exosome and human PM-Sc1 are related complexes of 3' --> 5' exonucleases
Article Abstract:
Human PM-Sc1 and the yeast exosome are discussed with information that they are related complexes of 3' --> 5' exonucleases, based on biochemical and genetic analyses that have found six novel components of the complex. The complex has 11 components, 10 of which are predicted to be 3' --> 5' exoribonucleaes, based on sequence homology. Strong indication that the PM-Scl complex is directly homologous to the yeast exosome has been found.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Distinct protein interaction domains and protein spreading in a complex centromere
Article Abstract:
Protein spreading in a complex centromere and distinct protein interaction domains are discussed. Fission yeast, Schizosaccharomyces pombe, centromeres are more evocative of higher eukaryotic centromeres than those of budding yeast. They are made up of large inverted repeats with heterochromatic features and are a good model, therefore, for higher eukaryotic centromeres.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. The regulation of the Drosophila msl-2 gene reveals a function for sex-lethal in translational control
- Abstracts: Use of the KlADH4 promoter for ethanol-dependent production of recombinant human serum albumin in Kluyveromyces lactis
- Abstracts: Steady-state nitrogen isotope effects of N2 and N2O production in Paracoccus denitrificans. Distribution of Nitrosomonas europaea and Paracoccus denitrificans immobilized in tubular polymeric gel for nitrogen removal
- Abstracts: Evidence for a role for the gumB and gumC gene products in the formation of xanthan from its pentasaccharide repeating unit by Xanthomonas campestris
- Abstracts: p53-mediated apoptosis is attenuated in Werner syndrome cells. Ku complex interacts with and stimulates the Werner protein