A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity

Article Abstract:

Research points out that in Drosophila, some ion channel genes exhibit specific A-to-I RNA editing mediated by the adenosine deaminase acting on RNA gene (ADAR) enzyme. Adult flies lacking ADAR show behavioral changes accompanied by neurodegeneration suggesting that A-to-I RNA editing of pre-mRNAs affects nervous system function.

United Kingdom, Statistical Data Included, Analysis, Behavior, Genetic aspects, Drosophila, Neurogenetics, Messenger RNA, Ion channels

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Alzheimer's disease: Neurodevelopment converges with neurodegeneration

Article Abstract:

This article discusses Alzheimer's disease pathology in relation to the intracellular signaling pathways and proteins genetically connected with the disease. Data suggest that a relationship exists between the disease associated genes and cognate proteins involved in the signaling pathways.

Research, Alzheimer's disease, Developmental neurology, Senile dementia

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A novel Ca(sup)2+ binding beta hairpin loop better resembles integrin sequence motifs that the EF hand

Article Abstract:

Authors present evidence to show similarities between calcium binding beta hairpin loop sequences and integrin protein sequences based on physical and chemical properties.

Proteins, Protein structure, Letter to the Editor, Calcium-binding proteins, Integrins, Calcium binding proteins

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