A toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling

Article Abstract:

A study is carried out on a stochastic lateral signaling interaction between two developing Caenorhabditis elegans AWC olfactory neurons causing them to take on asymmetric patterns of odorant receptor expression, called AWC(super OFF) and AWC(super ON). The studies show that the AWC lateral signaling gene tir-1 encodes a conserved post-synaptic protein that specifies the choice between AWC(super OFF) and AWC(super ON).

United States, Interleukin-1, Olfactory receptors

---

A missed exit: Reelin sets in motion Dab1 polyubiquitination to put the break on neuronal migration

Article Abstract:

Reelin pathway mutants have both activated and down-regulated its intracellular effector Dab-1 (Disabled-1) by inducing its phosphorylation that caused its targeting by an E3 ubiquitin ligase complex (EBC) containing SOCS family proteins and Cullin5 (Cul5). Impairment of down-regulation mechanism has led to a unique phenotype in the cortex where neurons have migrated past their target layer.

Glycoproteins, Phosphorylation, Ubiquitin, Ligases, Chemical properties

---

Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells

Article Abstract:

The presence of endogenous retinoid X receptor (RXR) ligands in the embryonic central nervous system (CNS) is demonstrated and shown that they can activate heterodimers formed between RXR and the orphan NR Nurr1 in vivo. Evidence for a role of Nurr1as a ligand-independent partner of RXR in its function as a bona fide ligand-activated nuclear receptor (NR) is provided.

Diseases, Central nervous system, Retinoids, Endogenous opioids

Similar abstracts:

• Abstracts: RNA editing in kinetoplastid protozoa. Molecular genetics of the RNA polymerase II general transcriptional machinery
• Abstracts: InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cyotoxic T cell-induced apoptosis
• Abstracts: Overexcited or inactive ion channels in muscle disease. The cadherin superfamily at the synapse: more members, more missions
• Abstracts: A complete estimate of the phylogenetic relationships in Ruminantia: A dated species-level supertree of the extant ruminants
• Abstracts: Molecular comparisons of freshwater and marine isolates of the same morphospecies of heterotrophic flagellates

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.