A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion
Article Abstract:
Researchers have investigated the role of a tyrosine-based sequence motif present in the cytoplasmic tail of the beta subunit of the H/K-ATPase in the targeting of this protein to a regulated compartment in vivo. This work involved mutagenizing the Tyr residue to Ala and producing transgenic mice expressing either the wild type or the mutagenized form of the H/K-ATPase beta subunit. It was established that the H/K-ATPase beta subunit tyrosine-based motif is required to prompt the removal of the H/K-ATPase from the apical membrane of parietal cells. The motif is also need to ensure that the H/K-ATPase is returned to the TVE compartment to stop the process of acid secretion.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts
Article Abstract:
The differentiation capacity of adult hematopoietic stem cells (HSC) is investigated by injecting HSCs from adult mice into blastocysts. Results reveal that adult HSCs survive in mouse embryos, further, the erythroid line synthesized fetal globin proteins. Conversely, embryonic erythroid progenies synthesize adult globin proteins when injected to adult mice. HSCs from adult mice exhibit gene expression plasticity depending on the environment.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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