Accommodating chromosome inversions in linkage analysis
Article Abstract:
A population-genetics model is developed for polymorphic chromosome inversions and the algorithms and software for allele-frequency estimation and linkage analysis in the presence of an inversion are described. The model has shown that allele frequencies and haplotype frequencies specific to normal and inverted chromosomes decay over time to predictable equilibrium values and the suppression of recombination between normal and inverted chromosomes have shown the approach to linkage equilibrium.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
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Bayesian linkage analysis, or: how I learned to stop worrying and love the posterior probability of linkage
Article Abstract:
Posterior probability of linkage (PPL) is a Bayesian technique of genetic linkage analyses assigning probabilities of linkage after review of the data. PPL lacks the strict statistical accuracy of the calculation of P values, but provides more useful predictions of genetic associations with complex diseases and traits.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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A Bayesian approach to copy-number-polymorphism analysis in nuclear pedigrees
Article Abstract:
The article represents a Bayesian graphical model that helps in the statistical evaluation of candidate copy-number-polymorphisms (CNPs). The model is also implemented in WinBUGS for analysis of nuclear families.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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