Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation
Article Abstract:
A report that the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) coactivator activity is potentiated by arginine methylation by protein arginine methyltransferase 1 (PRMT1), another nuclear receptor coactivator is presented. PGC-1alpha, a tissue-specific and inducible transcriptional coactivator for several nuclear receptors, plays a key role in energy metabolsim.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Plasticity and expanding complexity of the hepatic transcription factor network during liver development
Article Abstract:
Inactivation of HNF-4alpha in embryonic, but not in adult, liver results in the diminished expression of most hepatic factors, demonstrating that the stability of the network correlates with its complexity. These results illustrate the remarkable flexibility of a self-sustaining transcription factor network, built up by complex dominant and redundant regulatory motifs in developing hepatocytes.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Peroxisome proliferator-activated receptor-lambda coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR
Article Abstract:
A scientific experiment was carried out showing that peroxisome proliferator-activated coactivator 1alpha (PGC-1alpha) regulates adaptive thermogenesis and glucose metabolism. Ectopic expression of PGC-1alpha in murine primary hepatocytes reduces triglyceride secretion by a process that is dependent on the presence of Farnesoid X receptor (FXR).
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Partial characterization of a DNA restriction endonuclease from Ruminococcus flavefaciens FD-1 and its inhibition by site-specific adenine methylation
- Abstracts: Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. ABP1 is required for organized cell elongation and division in Arabidopsis embryogenesis
- Abstracts: Degradation of 1,2-dichloroethane by Ancylobacter aquaticus and other facultative methylotrophs. Multiphasic kinetics of transformation of 1,2,4-trichlorobenzene at nano- and micromolar concentrations by Burkholderia sp. strain PS14
- Abstracts: Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix. Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation
- Abstracts: At least two origins of fungicides resistance in grapevine downy mildew populations. Nitrogen-related hypermutator strain of Synechococcus sp. for use in vivo artificial evolution