Activity of microbial promoters during intracellular and extracellular growth

Article Abstract:

The conditions required for the examination of microbacterial promoter activity in mycobacteria grown in vitro and in replicating macrophages, containing a promoter, an RBS and start codon, have been developed. An 18 kDa gene is activated during the growth and possibly survival of mycobacteria within the macrophages. Mycobacteria such as Mycobacterium tuberculosis and Mycobacterium leprae responsible for tuberculosis and leprosy form an important group of microorganisms.

Observations, Promoters (Genetics)

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A 46kDa integral membrane protein from Mycobacterium leprae resembles a number of bacterial and mammalian membrane transport protein

Article Abstract:

The nucleotide sequence of a 3.4 kbp region of the Mycobacterium leprae (M.leprae) genome is described. The presence of 38L protein in the membrane protein fraction of M.leprae was demonstrated by using antibodies against 38L protein. There is a wide similarity between 38L protein and integral membrane proteins involved in the transport of small molecules through the cellular membrane. The 38L protein may be involved in the hypopigmentation observed in leprosy patients.

Biosynthesis, Protein tyrosine kinase, Protein-tyrosine kinase, Melanin, Leprosy research

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A highly immunogenic putative Mycobacterium kansasii lipoprotein

Article Abstract:

The immunogenic Mycobacterium kansasii lipoprotein, MK35, is an immunogenic antigen. The amino acid sequence of MK35 resembles that of other knownmycobacterial lipoproteins and possesses a consensus prokaryotic motif for lipidation. MK35 demonstrates abnormal electrophoretic mobility and induces delayed-type hypersensitivity reactions in sensitized guinea pigs. The study could help in the development of mycobacterial vaccines and diagnostic reagents.

Lipoproteins, Antigens

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