Agents that increase the permeability of the outer membrane
Article Abstract:
Antibacterial agents such as polycations and chelators exhibit permeability across the cell walls of gram-negative bacteria. These two agents disrupts the molecular interactions of the lipopolysaccharide segments of the outer membrane. Polycations attach themselves to anionic regions of these lipopolysaccharides of the membrane and cause the membrane to be susceptible to drug traversion. Some polycations possess other qualities aside from their cationic properties that make them better permeabilizers than others. Chelates destroys the outer membrane in order to cross the cell wall.
Publication Name: Microbiological Reviews
Subject: Biological sciences
ISSN: 0146-0749
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
The complete general secretory pathway in gram-negative bacteria
Article Abstract:
Protein transport across the cytoplasm of gram-negative bacteria by the general secretory pathway (GSP) requires hydrophobic amino acids. The translocation of hydrophilic polypeptides needs at least six different sec gene-encoded proteins and is dependent on ATP hydrolysis and the electrochemical potential. Other variants of the GSP terminal branch have been identified and presented.
Publication Name: Microbiological Reviews
Subject: Biological sciences
ISSN: 0146-0749
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Molecular biology of the symbiotic-pathogenic bacteria Xenorhabdus spp. and Photorhabdus spp
Article Abstract:
Molecular genetic studies of the phenotypically similar gram-negative gamma bacteria species Xenorhabdus and Photorhabdus showed differences in bioluminescence and lipase characteristics. Outer membrane protein examinations also led to the assumption that the phenotypic similarities of the two species could be from a horizontal convergence from different gene pools.
Publication Name: Microbiological Reviews
Subject: Biological sciences
ISSN: 0146-0749
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Anabolic incorporation of oxalate by Oxalobacter formigenes. Purification of two nitrate reductases from Xanthomonas maltophila grown in aerobic cultures
- Abstracts: DNA sequence variation at the period locus within and among species of the Drosophila melanogaster complex. Developmental arrest and ecdysteroid deficiency resulting from mutations at the dre4 locus of Drosophila
- Abstracts: Mutant lambda repressors with increased operator affinities reveal new, specific protein-DNA contacts. The effects of central asymmetry on the propagation of palindromic DNA in bacteriophage lambda are consistent with cruciform extrusion in vivo
- Abstracts: Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Structure, expression, chromosomal location and product of the gene encoding ADH2 in Petunia
- Abstracts: Mechanism of action of regulatory proteins encoded by complex retroviruses. part 2 The Rhizobium-plant symbiosis